Ketamine Administration Challenges

Discussions focus on the limitations of ketamine medical treatments, such as requiring supervised IV infusions or injections due to poor oral/nasal bioavailability, short-acting effects, side effects like k-holes, insurance issues, and desires for convenient alternatives like pills or home nasal sprays.

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Keywords

PMC12401705 EpiPen IM WA nlm.nih LAG GP en.m AND imperial.ac dose treatment drugs relief treatments injection effects shots antibodies doctor

Sample Comments

jitl β€’ Oct 24, 2022 β€’ View on HN

So far none of my doctors have proposed such treatment. It’s generally short-acting; probably not a good move for a therapeutic medication.

DanBC β€’ Nov 16, 2015 β€’ View on HN

That's a medically supervised dose after a rare event. GP post spoke about long term use.

pkaye β€’ Dec 11, 2022 β€’ View on HN

Hasn't this treatment been use for a while now?

rincebrain β€’ Feb 2, 2016 β€’ View on HN

The basic problem is that it requires IV infusion, not oral or nasal administration (trials of the latter have issues with consistent dosage, AIUI), and that requires trips to a doctor to do, weekly.

selimthegrim β€’ Dec 8, 2019 β€’ View on HN

I don't think they use the injectable version. I could be wrong.

darkerside β€’ Aug 26, 2020 β€’ View on HN

Dexamethasone and other medications and the evolving practices you mention are nothing to... sneeze at

mensetmanusman β€’ Nov 15, 2024 β€’ View on HN

Daily/weekly needle injections is the only defense?

bradly β€’ Jan 3, 2023 β€’ View on HN

With nasal spray would be difficult. Even sub-lingual would take quite a bit. IM and IV treatments can definitely cause a k-hole.

AuryGlenz β€’ Aug 29, 2023 β€’ View on HN

No, I was trying it for another medical condition. It worked most of the week other than the 2-3 days after injection where a side effect made that condition effectively worse, so it wasn't worth it.

pmontra β€’ Sep 21, 2016 β€’ View on HN

You're right but maybe they can turn that into pills or shots to be taken when needed.