Tylenol vs NSAIDs Safety

Cluster debates the relative safety of acetaminophen (Tylenol/paracetamol) versus NSAIDs like ibuprofen and aspirin, focusing on liver toxicity, overdose risks, gastrointestinal bleeding, and kidney effects.

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US MUCH NSAID harvard.edu ACL usage.html EUR lysine.html gssiweb.org GR dose liver drugs dosage drug pain headache alcohol effect taking

Sample Comments

tcoff91 Oct 25, 2023 View on HN

I'm pretty sure you have it backwards. Tylenol/Acetaminophen is quite hard on the liver.https://www.health.harvard.edu/press_releases/acetaminophen_....

m463 Aug 25, 2025 View on HN

maybe should add (tylenol) to the article subject?

slowmovintarget Mar 30, 2022 View on HN

After going nearly a year without taking painkillers of any kind (not an aspirin, ibuprofen, or acetaminophen dose), I took some Tylenol for a bad headache, and it worked far better than it had ever worked for me before.Granted, I've had to learn to put up with a lot more constant low-level pain in my day-to-day life. But I think that's a reasonable trade off for choosing between cooking my kidneys (aspirin, ibuprofen) or blowing out my liver (acetaminophen).I had a really weird

aidenn0 Sep 7, 2016 View on HN

I thought Tylenol killed many more people than all the NSAIDs combined?

montecarl Sep 4, 2016 View on HN

This is actually not that different from the therapeutic index of paracetamol (Tylenol)[1]. Paracetamol is a super safe drug when used exactly as directed (both dosage and not taking with alcohol), but taking any more than prescribed can be fatal.[1] https://en.wikipedia.org/wiki/Paracetamol_toxicity

vidarh Jul 12, 2024 View on HN

Because NSAIDs can lead to erosion and bleeding in your gut.I've been told to avoid NSAIDs "forever", or at least until a gastroscopy has shown my stomach is fully recovered after using ibuprofen strictly within the dose limits. It's a known risk, and lowering the dose just reduces the odds - it doesn't remove the risk.Acetaminophen/paracetamol overdoses do happen, but they're rare and usually involve significant overdoses rather than minor accidental exc

badpun Feb 24, 2024 View on HN

Aspirin or Ibupofren have their limits.

leoedin Mar 24, 2020 View on HN

Paracetamol (acetaminophen/Tylenol) is not an NSAID, is not an anti-inflammatory and there's no evidence that it has any negative effect on outcomes. You're mixing it up with ibuprofen (Advil), which is an NSAID and may result in worse outcomes.The current medical advice is take paracetamol, but not ibuprofen. https://www.nhs.uk/medicines/paracetamol-for-ad

snotrockets Jan 29, 2018 View on HN

Both of them (Acetaminophen is the US name for Paracetamol) are highly dangerous, even in small dosages. Paracetamol poisoning can kill within a day, and the lethal dosage is equivalent to about 20 pills. Ibuprofen is proven to cause heart attacks & stroke.Your suggestion is the perfect example of why over the counter drugs as so dangerous: a Dr or a pharmacist is aware of the dangers, that we (being the public) may not know about, and should not dispense those without taking them into ac

freeone3000 Feb 7, 2021 View on HN

Well, lucky for you, both (in fact, all three) are still available. But, as a statistical matter, Ibuprofen is safer. Not only because the liver is such a contentious point for drug elimination, including alcohol, but due to the ability to fix overdoses. Even with minor overdoses (such as mixing with alcohol), paracematol causes permanent liver damage, whereas stomach ulcers can be repaired. More than 100,000 people die annually from Paracematol overdoses. Ibuprofen is sold more, and has fewer t