Gain-of-Function Research

This cluster focuses on gain-of-function research on viruses, especially coronaviruses, including debates on its risks, benefits, lab safety, and potential links to COVID-19 origins like lab leaks from the Wuhan lab.

πŸ“‰ Falling 0.2x Science
3,347
Comments
19
Years Active
5
Top Authors
#3895
Topic ID

Activity Over Time

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Keywords

COV US technologyreview.com newsweek.com NIH nature.com I.e SARS BSL DIY viruses research virus lab gain function sars sars cov cov labs

Sample Comments

ignoramous β€’ Mar 21, 2020 β€’ View on HN

What's the possibility of creating such a virus in a lab?

monort β€’ Jan 25, 2020 β€’ View on HN

Actually scientists are working on super viruses, it's called gain of function.https://www.nature.com/articles/d41586-017-08837-7

DocTomoe β€’ Nov 24, 2021 β€’ View on HN

The genie is out of that bottle - the research has been done, and can be replicated by less honest actors. Under these circumstances, continuing this kind of research to understand how to combat viruses created by rouge actors might be the right thing to do.

sneak β€’ Sep 6, 2022 β€’ View on HN

People are creating super viruses, regardless of the origin of this one.Act accordingly.

ljsprague β€’ Nov 26, 2025 β€’ View on HN

Are they still doing gain-of-function research on viruses?

ObscureScience β€’ Nov 5, 2023 β€’ View on HN

Is anyone even suggesting a genetically modified virus?

burfog β€’ Apr 13, 2020 β€’ View on HN

Neither extreme seems likely.We know that the lab was adding functionality to bat coronaviruses, making them able to infect human cells. This can be done without gene editing technology. We've been doing that in the opposite direction for decades, passing viruses through non-human cells in order to make weakened ones for live-virus vaccines. To make a virus worse for humans, simply pass it through human cells. This is what the lab was doing.It's extremely hazardous research. The

slenk β€’ May 17, 2021 β€’ View on HN

Depends on what you view as natural. They have been doing "Gain of Function" research which is designed to enhance viruses.https://www.newsweek.com/controversial-wuhan-lab-experiments...

raxxorrax β€’ Jul 7, 2020 β€’ View on HN

I think researching how these viruses can become dangerous to humans is the main goal in research like this. That a natural mutation would look similar speaks for their expertise and isn't necessarily controversial. It should be controversial if lax security measures would permit viruses to spread from a lab. We have absolutely no evidence of this to my knowledge and should be careful with accusations.

benreesman β€’ Nov 8, 2022 β€’ View on HN

I think everyone agrees that observing live virus in the lab is a critical (if dangerous) part of studying them.Intentionally engineering them as high as possible on transmissibility and morbidity is bioweapon development being money laundered through conventional science: it’s an insane thing to do.Leaving SARS-COV-2 out of it completely: there have indisputably been other leaks. It’s the height of irresponsibility and shortsightedness to engineer civilization-ending viruses, which