Alzheimer's Amyloid Hypothesis
Cluster focuses on debates challenging the amyloid plaque hypothesis as the primary cause of Alzheimer's disease, citing new research, alternative theories like insulin resistance, infections, and inflammation, and related studies.
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Now explain how it could affect Alzheimers
New research shows amyloids may not be the cause of Alzheimers [1].[1]https://www.cbc.ca/radio/quirks/dec-8-2018-why-are-users-tak...
Paper in Alzheimer's Research and Treatment journal: https://alzres.biomedcentral.com/articles/10.1186/s13195-025...
Honestly, by pointing to your comments from previous discussions, you look like you have an ax to grind rather than being helpful.The truth is that we don't know what causes Alzheimer's. Amyloids may or may not play as much of a role as some people think. But without a better hypothesis to test and get funding for, this is what they can do.
See related :"Alzheimer’s amyloid hypothesis ‘cabal’ thwarted progress toward a cure (2019)"https://news.ycombinator.com/item?id=31828509https://news.ycombinator.com/item?id=21911225(also see dang's comment who lists 2 more thread <a href="https:/
yeah strongly agree. it was thought that those plaques in the brain was the cause of alz; however, some research has indicated that's the body's defense against what is going on, not the cause. so you could take a medication that lowers GDF15, and its possible it actually increases the onset of dementia.
You might be interested in "Beyond Amyloid": https://www.statnews.com/2017/08/18/beyond-amyloid-alzheimer...
doesn’t this still support the amyloid hypothesis? i hear there’s many different theories for Alzheimer’s now
My understanding was the beta-amyloid hypothesis itself is under some amount of scrutiny and may not truly explain Alzheimer's. Wonder if this finding adds more evidence for the amyloid hypothesis.
This is linking to an alzheimers drug and not related to your headline. I think there has been a mistake.